Case Report Emergence of Resistance to Third-Generation Cephalosporin in Shigella—A Case Report
نویسندگان
چکیده
The emergence of ciprofloxacin resistance in Shigella has shifted the attention to cephalosporins. The first occurrence of third generation cephalosporin-resistant Shigella flexneri was from France. This article reports the first case of cephalosporin-resistant S. flexneri from India. A 12-month-old child was admitted for a 20-day episode of loose stools, non-fetid, with mucus and blood. The stool sample showed the presence of blood and mucus and S. flexneri which was resistant to Ampicillin, Nalidixic acid, Ciprofloxacin, Furoxone, Ceftriaxone and sensitive only to Cefoperazone and sulbactam combination. The child was promptly admitted and treated with a combination of Cefoperazone and sulbactam. The use of this combination was met with success in the present case, and may be considered as a temporary answer to the emerging cephalosporin-resistance.
منابع مشابه
Extended-spectrum ß-lactamase production in Shigella flexneri.
Emergence of multidrug-resistant strains of Shigella is a growing concern across the globe. Third-generation cephalosporins are used for treating infections caused by multidrug-resistant Shigellae. However, resistance to these cephalosporin antibiotics due to extended-spectrum ß-lactamases, has emerged as a new problem. So far extended-spectrum ß-lactamases producing Shigella has not been repor...
متن کاملIdentification of Shigella species and their antibiotic resistance patterns from dysenteric patients in Baradaran Rezaei hospital of Damghan, Northeast of Iran
Shigella is a major cause of dysentery across the world. Appropriate antibiotic treatment of shigellosis depends on resistance patterns. The present study was conducted to identify Shigella species and their antibiotic resistance patterns among dysenteric patients in Rezaei Hospital of Damghan. Isolation of Shigella species was conducted by specific culture medium and biochemical tests. The Shi...
متن کاملShigellosis Caused by CTX-M Type ESBL Producing Shigella flexneri in Two Siblings of Rural Nepal: First Case Report from the Country
Shigellosis is an acute infectious disease characterized as severe bloody diarrhea (dysentery) and is accountable for a significant burden of morbidity and mortality especially in children under the age of 5 years. Antimicrobial therapy is required in the cases of severe dysentery associated with Shigella. However, emergence of multidrug resistant (MDR) strains of Shigella spp. over the last tw...
متن کاملHealth and economic outcomes of the emergence of third-generation cephalosporin resistance in Enterobacter species.
BACKGROUND This study evaluated the clinical and economic impact of the emergence of third-generation cephalosporin-resistant Enterobacter species. METHODS Mortality, length of hospitalization, and hospital charges were examined in a cohort that was selected from a group of 477 patients with initial cultures that yielded a third-generation cephalosporin-susceptible Enterobacter species. Case ...
متن کاملThird-generation cephalosporin resistance in Shigella sonnei, Argentina.
Shigella sonnei resistant to cefotaxime (but not to ceftazidime) was isolated for the first time in stool samples from a pediatric patient with vomiting and bloody diarrhea in northern Argentina. Microbiologic and biochemical tests confirmed the presence of an extended spectrum beta-lactamase displaying an apparent isoelectric point value of 8.2.
متن کامل